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Objective To investigate the influence of compound salvia injection on oxidative stress and complications in patients with gestational hypertension.Methods From August 2015 to Fabuary 2017,140 patients with gestational hypertension in Binzhou Central Hospital were selected as study objects ,and randomly divided into control group and research group according to the digital table ,with 70 cases in each group.The control group was treated with routine treatment ,the research group was given routine treatment combined with compound salvia injec-tion.After treatment,SOD,MDA,NO,HMGB1,Cys C,hs-CRP,TNF-α,blood pressure and complications between the two groups were compared.Results After treatment,the levels of NO[(942.58 ±80.69)mmol／L vs.(734.51 ± 78.63)mmol／L] and SOD[(124.65 ±23.81)U／mL vs.(90.64 ±24.13)U／mL] in the research group were higher than those in the control group ,and the MAD level [(10.47 ±3.14) nmol／L vs.(15.82 ±3.32) nmol／L] in the research group was lower than that in the control group ,the difference were statistically significant between the two groups(t＝15.451,8.394,9.795,all P＜0.05).After treatment,the levels of HMGB1 [(1.81 ±0.43) mg／L vs. (3.89 ±0.65)mg／L],Cys C[(1.04 ±0.18)mg／L vs.(1.42 ±0.27) mg／L],TNF-α[(15.09 ±3.14) ng／L vs. (21.45 ±4.78) ng／L] and hs-CRP[(3.04 ±0.81) mg／L vs.(6.32 ±1.45) mg／L] in the research group were lower than those in the control group ,the differences were statistically significant (t＝22.329,9.798,9.304,16.523, all P＜0.05).After treatment,the systolic blood pressure[(131.25 ±5.74)mmHg vs.(139.61 ±5.59)mmHg] and diastolic blood pressure[(85.23 ±5.07)mmHg vs.(90.43 ±5.81) mmHg] in the research group were lower than those in the control group(t＝8.730,5.642,all P＜0.05).The cesarean section rate (61.43% vs.87.14%) and intrauterine distress rate(1.43%vs.11.43%) in the research group were lower than those in the control group (χ2 ＝12.115,5.818,all P＜0.05).Conclusion Compound salvia miltiorrhiza injection has significant control effect on oxidative stress and inflammatory reaction in patients with gestational hypertension ,and is beneficial to reduce the complications of childbirth.
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Objective@#To investigate the influence of compound salvia injection on oxidative stress and complications in patients with gestational hypertension.@*Methods@#From August 2015 to Fabuary 2017, 140 patients with gestational hypertension in Binzhou Central Hospital were selected as study objects, and randomly divided into control group and research group according to the digital table, with 70 cases in each group.The control group was treated with routine treatment, the research group was given routine treatment combined with compound salvia injection.After treatment, SOD, MDA, NO, HMGB1, Cys C, hs-CRP, TNF-α, blood pressure and complications between the two groups were compared.@*Results@#After treatment, the levels of NO[(942.58±80.69)mmol/L vs.(734.51±78.63)mmol/L] and SOD[(124.65±23.81)U/mL vs.(90.64±24.13)U/mL] in the research group were higher than those in the control group, and the MAD level[(10.47±3.14)nmol/L vs.(15.82±3.32)nmol/L]in the research group was lower than that in the control group, the difference were statistically significant between the two groups(t=15.451, 8.394, 9.795, all P<0.05). After treatment, the levels of HMGB1[(1.81±0.43)mg/L vs.(3.89±0.65)mg/L], Cys C[(1.04±0.18)mg/L vs.(1.42±0.27)mg/L], TNF-α[(15.09±3.14)ng/L vs.(21.45±4.78)ng/L] and hs-CRP[(3.04±0.81)mg/L vs.(6.32±1.45)mg/L] in the research group were lower than those in the control group, the differences were statistically significant(t=22.329, 9.798, 9.304, 16.523, all P<0.05). After treatment, the systolic blood pressure[(131.25±5.74)mmHg vs.(139.61±5.59)mmHg] and diastolic blood pressure[(85.23±5.07)mmHg vs.(90.43±5.81)mmHg] in the research group were lower than those in the control group(t=8.730, 5.642, all P<0.05). The cesarean section rate(61.43% vs.87.14%) and intrauterine distress rate(1.43% vs.11.43%) in the research group were lower than those in the control group(χ2=12.115, 5.818, all P<0.05).@*Conclusion@#Compound salvia miltiorrhiza injection has significant control effect on oxidative stress and inflammatory reaction in patients with gestational hypertension, and is beneficial to reduce the complications of childbirth.
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Objective To investigate the clinical curative effect and the influence on knee joint function of knee osteoarthritis treating with sodium hyaluronate combined with compound salvia injection.Methods 78 patients with osteoarthritis treated in our hospital from June 2015 to August 2016 were randomly divided into three groups: sodium hyaluronate group, compound salvia injection group and sodium hyaluronate plus compound salvia injection combination therapy group, 26 cases each group.The levels of serum inflammatory cytokines (IL-6,TNF-αand IL-1β) were measured by ELISA before and after treatment in the three groups, and the improvement of knee joint function and the change of pain score before and after treatment were analyzed as well.Results The total effective rate of sodium hyaluronate combined with compound salvia injection was significantly higher than that of sodium hyaluronate and compound salvia injection alone ( P <0.05 ); after treatment, patients VAS pain score was significantly decreased ( P <0.05), and the VAS pain scores in the combination group were significantly lower than those of the group treated with sodium hyaluronate and the compound salvia injection (P<0.05).The levels of IL-6, TNF-αand IL-1βin the three groups were significantly lower than those before treatment (P<0.05),and the inflammatory factors in the combination group were significantly lower than those in the alone treatment group (P <0.05). Conclusion Sodium hyaluronate combined with compound salvia injection has good clinical curative effect on knee osteoarthritis,improving the function of knee joint, reducing pain and so on.
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Objective To study the influence of Compound Salvia injection combined with cefoperazone sulbactam sodium on renal function and renal interstitial fibrosis in elderly patients with chronic pyelonephritis (CPN).Methods From April 2013 to July 2014, 126 cases of CPN were divided into observation group ( n =63 ) and control group ( n =63 ) according to the order of admission to hospital.All patients were given cefoperazone sulbactam sodium, and patients in observation group were added Compound Salvia injection.The clinical efficacy of treatment were evaluated between two groups, renal function and TGF-β1 were observed and compared before and after treatment in two groups.Results After treatment, HE staining of nephridial tissue showed renal interstitial fibrosis in observation group obvious improved more.The overall response rate of observation patients (90.48%) was significantly higher (74.60%) than control group, and the relapse rate of observation group (1.59%) was significantly lower than control group (14.29%), and there were statistically significant differences (P<0.05).After treatment, urinary albumin (11.4 ±3.1) mg/L, BUN (5.7 ±0.5) mmol/L, and Scr (103.2 ±10.4)μmol/L of observation group were significantly lower than control group, respectively (P<0.05).After treatment, TGF-β1 level (103.4 ±32.5) ng/L of observation group was significantly lower than control group (202.4 ±35.2) ng/L(P<0.05).There was no significant difference in adverse reactions between two groups.Conclusions Compound Salvia injection combined with cefoperazone sulbactam sodium has good efficacy.can significantly improve renal function, delay renal interstitial fibrosis in treatment of elderly patients with chronic pyelonephritis.